Selected Publications
Spatial organization of the extracellular matrix regulates cell–cell junction positioningTseng Q, Duchemin-Pelletier E, Deshiere A, Balland M, Guilloud H, Filhol O, Théry M PNAS published online January 17, 2012 Keywords: Cell cell junctions Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1 Keywords: lysosomes Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STILKitagawa D, Kohlmaier G, Keller D, Strnad P, Balestra F, Flückiger I, Gönczy P J Cell Sci. 2011 Nov 15;124(Pt 22):3884-93. Keywords: microcephaly, mitotic spindle orientation The role of RPGR in cilia formation and actin stability. Gakovic M, Shu X, Kasioulis I, Carpanini S, Moraga I, Wright AF. Hum Mol Genet. 2011 20(24):4840-50 . Keywords: ciliogenesis, retinal dystrophy MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD. Nature Cell Biol. 2011 Aug 7;13(9):1040-50. Keywords: mitotic spindle orientation, H pattern Intercellular and extracellular mechanotransduction in cardiac myocytes. Kresh JY, Chopra A. Pflugers Arch. 2011 Jul;462(1):75-87. Keywords: adult cardiomyocytes, extracellular matrix, mechanical determinants, cytoskeletal organization, shape remodelling, sarcomere/myofibrillar architectural topography, cell shape-dependent functions, myopathies, myocardial infarctus, heart failure, reverse remodeling, disk-, H-, Y-, crossbow-shaped micropatterns, sarcomeric alpha-actinin. Role of YAP/TAZ in mechanotransduction Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N & Piccolo S Nature 2011 Jun 9; 474:179 Keywords: mechanotransduction, differentiation of mesenchymal stem cells The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton. Lombardi ML, Jaalouk DE, Shanahan CM, Burke B, Roux KJ, Lammerding J. J Biol Chem. 2011 Jun 7. Keywords: nucleo-cytoskeletal coupling, force transmission, LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, intracellular forces, nuclear positioning, cell polarization, muscular dystrophies, cardiomyopathies, crossbow-shaped micropatterns Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis. Hurtado L, Caballero C, Gavilan MP, Cardenas J, Bornens M, Rios RM. J Cell Biol. 2011 May 30;193(5):917-33. Keywords: pericentrosomal Golgi ribbon organization, AKAP450 N-terminal fragments, microtubule nucleation, centrosomal activity, Golgi apparatus positioning, directional cell migration, ciliogenesis, Y-shaped micropatterned coverslips Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB. Cancer Res. 2011 Jan 1;71(1):134-42. Keywords: high-throughput screen, clear cell renal cell carcinoma (CCRCC), Von Hippel-Lindau (VHL) tumor suppressor gene, Golgi sequestration, P-gp-mediated localization of anticancer compounds, disk- and L-shaped fibronectin micropattern Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA. Badyal SK, Basran J, Bhanji N, Kim JH, Chavda AP, Jung HS, Craig R, Elliott PR, Irvine AF, Barsukov IL, Kriajevska M, Bagshaw CR. J Mol Biol. Jan 2011 Keywords: epidermoid carcinoma A431/SIP1 cells constitutively expressing the GFP-tagged heavy chain of non-muscle myosin IIA, medium Y-shaped fibronectin micropattern Micropatterning as a tool to decipher cell morphogenesis and functions. J Cell Sci. 2010 Dec 15;123(Pt 24):4201-13. Review. Probabilistic density maps to study global endomembrane organization. Schauer K, Duong T, Bleakley K, Bardin S, Bornens M, Goud B. Nat Methods. 2010 Jul;7(7):560-6. Keywords: endomembranes, small G proteins Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells. Pitaval A, Tseng Q, Bornens M, Théry M. J Cell Biol. 2010 Oct 18;191(2):303-12. Keywords: Primary cilium Cells in tight spaces: the role of cell shape in cell function. Shah JV. J Cell Biol. 2010 Oct 18;191(2):233-6. Keywords: cell shape, cell function, ciliogenesis Improved visualization and quantitative analysis of drug effects using micropatterned cells. Degot S, Auzan M, Chapuis V, Béghin A, Chadeyras A, Nelep C, Calvo-Muñoz ML,Young J, Chatelain F, Fuchs A. J Vis Exp. 2010 Dec 2;(46). Keywords: Reference Cell, drug profiling, quantitative cell analysis Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Genes Dev. 2008 Aug 15;22(16):2189-203. Keywords: tumor cells, micropatterns, H shape, Y shape, cell division Experimental and theoretical study of mitotic spindle orientation. Théry M, Jiménez-Dalmaroni A, Racine V, Bornens M, Jülicher F. Nature. 2007 May 24;447(7143):493-6. Keywords: mitotic spindle orientation, cell microenvironment geometry, cortical cues, spindle pole, symmetric/ asymmetric orientation Cell distribution of stress fibres in response to the geometry of the adhesive environment Théry M, Pépin A, Dressaire E, Chen Y, Bornens M. Cell Motil Cytoskeleton. 2006 Jun;63(6):341-55. Keywords: pattern geometry, apices of cell shape, stress fibres formation, focal adhesions, tractional forces, determination of cell shape in response to external adhesive conditions Théry M, Racine V, Piel M, Pépin A, Dimitrov A, Chen Y, Sibarita JB, Bornens M. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19771-6. Keywords: cell polarity, cell-extracellular matrix, tissue morphogenesis, cell normalization, organelle positioning, orientation of cell polarity axis The extracellular matrix guides the orientation of the cell division axis. Théry M, Racine V, Pépin A, Piel M, Chen Y, Sibarita JB, Bornens M. |
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