Technology overview

Throughout the CYTOO micropattern array, cells adopt the same architecture

Settled on a concave micropattern, cells adopt the convex envelope stretching out over the non adhesive surface.
The geometric distribution of adhesive contacts between cell and substrate induces the reproducible polarization of the cell machinery.
Cell position, cell shape, cell polarity and internal cell organization are standardized.

Cell mapping

The normalization of cell shape and behaviour is the first step to robust and reliable quantification. A heat map of the distribution of cell components can be obtained by stacking images and averaging the results over a statistically relevant number of individual cells. Learn more

Immediate benefits: Straightforward analysis, reliable results and faster discovery

• Reduce cell to cell variability
• Control the position of cell compartments and protein networks
• Achieve simple and rapid image analysis
• Map a "standard" averaged cell and use it as a reference

Application assays:
Cell biology and high throughput screening

• Cytoskeleton architecture, contractility.
• Organelle morphology.
• Protein profiles and colocalizations.
• Cell polarity.
• Symmetric and asymmetric cell division.
• Receptor internalization..